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Drug induced mitochondrial dysfunction Mechanisms and ~ Drug induced mitochondrial dysfunction may be a consequence of increased production of reactive oxygen species altered mitochondrial permeability transition impaired mitochondrial respiration mitochondrial DNA damage or inhibition of betaoxidation of fatty acids

Drug‐Induced Mitochondrial Dysfunction Wiley Online Books ~ Dr Dykens has published extensively on druginduced mitochondrial dysfunction on the role of mitochondrial free radical production in the etiology of neurodegenerative diseases and on the physiological ecology of marine symbioses

DrugInduced Mitochondrial Dysfunction Drug Discovery ~ Dr Dykens has published extensively on druginduced mitochondrial dysfunction on the role of mitochondrial free radical production in the etiology of neurodegenerative diseases and on the physiological ecology of marine symbioses Yvonne Will PhD works in Pfizers Exploratory Safety Differentiation Group in Groton Connecticut Prior to this position she led Pfizers Investigative Biochemical Toxicity Group within the Drug Safety Research and Development Department in La Jolla

Drug induced mitochondrial dysfunction Mechanisms and ~ Drug induced mitochondrial dysfunction is associated with many adverse drug reactions Drugs can affect mitochondria directly by inhibiting ETC mtDNA transcription protein production and ATP synthesis Increased ROS production can contribute to mitochondrial dysfunction indirectly by damaging mtDNA and the OXPHOS system

Mitochondrial Dysfunction Caused by Drugs and ~ Drug and Environmental Induced Mitochondrial Dysfunction provides ample reminders of the intimate connections between mitochondria pharmacology and toxicology The book takes a rather systematic approach to mitochondrial pharmacology and toxicology and for this reason will be of use to even those outside of strict drug discovery

Mitochondrial dysfunction as a mechanism of druginduced ~ Many risk factors predispose epileptic patients to idiosyncratic druginduced mitochondrial dysfunction 155181182 These risk factors are typically drugspecific and determination of clinical manifestations for diagnosis and prognosis of hepatotoxicity in a particular patient is difficult 183

Druginduced mitochondrial dysfunction and cardiotoxicity ~ The final phase of mitochondrial dysfunction induces loss of mitochondrial membrane potential and an increase in mitochondrial oxidativenitrative stress eventually culminating into cell death This review aims to discuss the mechanisms of mitochondrionmediated cardiotoxicity of commonly used drugs and some potential cardioprotective strategies to prevent these toxicities

Druginduced mitochondrial dysfunction and cardiotoxicity ~ drugs may induce mitochondrial dysfunction Mitochondrial replication is a specific process that is required to maintain a “healthy” mitochondrial population The antiviral nucleotide reverse transcriptase inhibitors are interfering with the action of the polymerase of the mitochondrial DNA thereby inhibiting mitochondrial replication

DrugInduced Mitochondrial Toxicity SpringerLink ~ Drugs can induce mitochondrial dysfunction by different mechanisms including inhibition of fatty acid oxidation impairment of oxidative phosphorylation and respiratory chain activity as well as alteration of the integrity of the mitochondrial membranes